Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of a combination of donepezil tablets and butylphthalide soft capsules on neurological function in dementia patients, and its effect on serum inflammatory factors

Fuqiang Ma¹, Tao Chen², Yanqiu Wang², Junxia Xu³ ,

¹Department of Laboratory, Tongwei County Hospital of Traditional Chinese Medicine, Dingxi 743300, China; ²Department of Laboratory, Gansu Province Hospital Rehabilitation Center, Lanzhou 730000, China; ³Department of Laboratory, Longxi County Hospital of Traditional Chinese Medicine, Dingxi 743300, Gansu Province, China.

For correspondence:- Junxia Xu Email: xfpv57@163.com Tel:+8615393240632

Accepted: 5 February 2022 Published: 28 February 2021

Citation: Ma F, Chen T, Wang Y, Xu J, Effect of a combination of donepezil tablets and butylphthalide soft capsules on neurological function in dementia patients, and its effect on serum inflammatory factors. Trop J Pharm Res 2022; 21(2):375-380 doi: 10.4314/tjpr.v21i2.21

© 2022 The authors.
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Abstract

Purpose: To determine the effect of combined use of donepezil tablets and butylphthalide soft capsules in the treatment of patients with vascular dementia, and its effect on serum inflammatory factor levels and neurological functional recovery of patients.

Methods: 120 patients with vascular dementia were selected and assigned to group A (n = 60) and group B (n = 60). All patients were treated with donepezil tablets, while patients in group A were, in addition, treated with butylphthalide soft capsules. Mini mental state examination (MMSE) scores, clinical dementia rating scale (CDRS) scores, activities of daily living (ADL) scores, incidence of adverse reactions, serum inflammatory factor levels and neurological functional recovery were determined.

Results: There was significantly higher MMSE score in group A than in B, while CDRS score was lower in group A. The ADL scores and inflammatory factor levels were lower in group A than in B (p < 0.001), while neurological functional recovery was markedly better in A (p < 0.001). Incidents of unwanted events were comparable in groups A and B, and there were no serious complications in the patients.

Conclusion: The combination therapy of donepezil tablets and butylphthalide soft capsules reduces inflammatory factor levels and improved cognitive level and quality of life of patients with vascular dementia. It also produces good neurological functional recovery and low incidence of adverse reactions. Therefore, this treatment strategy has potentials for the management of vascular dementia.

Keywords: Vascular dementia, Donepezil tablets, Butylphthalide soft capsules, Neurological function, Inflammatory factors